Studies of multiple antioxidants against oxidative dam- age have both practical and theoretical significance due to two primary reasons. Balanced human diets contain multiple antioxidants. In addition to the antioxidative protection contributed by individual dietary antioxi- dants, strong evidence indicates that additive and syn- ergistic interactions occur among antioxidants. This synergism significantly strengthens the protection pro- vided by individual antioxidants alone.
对抗氧化损伤的多种抗氧化剂的研究具有实际和理论意义,主要是由于两个主要原因。平衡人类膳食中含有多种抗氧化剂。除了单个膳食抗氧化剂的抗氧化保护作用,强有力的证据表明抗氧化剂之间具有附加和协同的相互作用。该协同作用显著的加强单个抗氧化剂提供的保护上海翻译公司。
Recently a heme protein spectra analysis program (HPSAP) has been used to evaluate the protection of multiple antioxidants against heme protein oxidation (OHP) in a tissue slice system or homogenates of tis- sues. 7 The study showed that diet supplemented with vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, Beta-carotene, canthaxanthin, coen- zyme Q0, coenzyme Q~o, and (+)-catechin provided better protection against heme protein oxidation than diet supplemented with fewer varieties and decreased concentrations of antioxidants.
To approximate more closely the in vivo situation,
最近采用一个血红素蛋白光谱分析项目(HPSAP)评价组织切片系统或组织匀浆中多种抗氧化剂对抗血红素蛋白氧化(OHP)的保护作用。7研究表明添加维生素E、硒、trolox C、抗坏血酸棕榈酸酯、乙酰半胱氨酸、β-胡萝卜素、斑蝥黄、辅酶Q0、辅酶Q10和(+)-儿茶素的膳食与添加更少种类和更低浓度抗氧化剂的膳食相比,提供对抗血红素蛋白氧化的更好保护翻译公司。
fresh blood and tissue slices without incubation can be studied in similar experiments. In this study rats were fed diets supplemented with various combinations of antioxidants for 6 weeks before intraperitoneal injec- tion with CBrCI3, a potent inducer of oxidative dam- age. Protection against oxidative damage by multiple antioxidants was evaluated by measuring the formation of oxidized heme proteins (OHP) in rat blood and tis- sue slices under experimental conditions close to the in vivo state.
育的新鲜血液和组织切片。在本研究中,给大鼠饲喂补充各种抗氧化剂复合剂的膳食6周,随后腹腔内注射CBrCl3,这是氧化损伤的一种高效诱导剂。通过测量接近体内状态的实验条件下大鼠血液和组织切片中的氧化血红素蛋白(OHP),评价多种抗氧化剂针对氧化损伤的保护作用